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Kohaku’s sister, village priestess Ruri, is gravely ill. Senku, Chrome and Kohaku begin their quest to make antibiotics to save her life.

Kohaku shows Senku to her village, but it’s going to take some convincing before they let him in. In the meantime, he makes friends with a like-minded, promising “sorcerer.”

Taiju and Yuzuriha figure out Senku’s secret to reviving him. But now that he’s back, they need to deal with Tsukasa.

Tsukasa demands that Senku abandons science, but there’s no way he can do that. Tsukasa is left with no choice but to kill him.

Senku, Taiju and Yuzuriha head to Hakone to collect sulfur for gunpowder, which they’ll need to fight Tsukasa. They accidentally set off an explosion, which attracts some unexpected attention.

Tsukasa has learned about the cave where the nitric acid is collected. The race is on between Senku and Tsukasa to restore humanity in their respective visions.

Senku and the kingdom learns of a mysterious disc left behind by his father and the other astronauts. They use their newfound technology to bring it to life.

Now that the kingdom of science has access to tungsten, they can finish building the cell phone.

Senku, Magma and Chrome explores a cave for tungsten, which they’ll need to make durable filaments for their cell phone vacuum tubes. But Magma has other plans in mind.

Making cell phones takes a lot of materials and tools. Senku begins by upgrading their equipment using the waterwheel Chrome and Kaseki invented and built together.

Tsukasa plans a second attack after a few months of preparation. He has no idea what Senku and his kingdom are cooking up in the meantime.

Taiju and Senku are about to revive Yuzuriha, when they get attacked by lions.

Tsukasa’s army attacks the village. Outmatched by the attackers, they have to rely on wits, cooperation and science to fend them off.

Tsukasa’s army attacks the village, potentially leaving them with no choice but to cut down the bridge and lose Kinro.

Through Byakuya’s message to Senku, we learn of the events that started Ishigami Village.

Having won the Grand Bout fair and square, and having cured village priestess Ruri of her pneumonia, Senku has won the hearts and minds of the village. Ruri delivers Senku a message from someone dear.

With Magma defeated, it’s down to Senku and Ginro to take the throne. Although both are on the same team, one is driven by personal greed and opportunism. The fight is on!

The Grand Bout is on. The kingdom of science must defeat Magma and take the seat of the village chief in order to give Ruri the antibiotic and win over the village.

All that’s needed to make antibiotics is alcohol. The best way to get some is to win the Grand Bout, which the Senku and his kingdom will also need to do in order to keep Magma away from Ruri and give her the drug.

To make antibiotics, Senku and his kingdom need to obtain sulfuric acid from a fountain of the stuff. The team goes prepared, but there’s no guarantee that they’ll make it back alive.