Izetta is powerful enough to fight whole armies, but her strength is limited. She can only use her abilities near certain ley lines, and outside them, she's no different than a normal girl. When the Germanian army attacks in a spot far from these ley lines, the duchy is forced into a corner: how can they repel these foes without giving up the secret of Izetta's strength?

With Izetta's victory over the Germanian army fresh in people's minds, the army of the Dukedom decides to make her into a national icon and announce her to the world. She's given the finest white dress they have to offer and a huge ceremony is arranged with journalists from all over the globe. But before she can be used in combat, they need to unravel the secret of her strength, which means she must travel to a hidden location with a girl who doesn't like her very much at all.

The Germanians forces are rolling up an important strategic area, and it's only a matter of time before the dukedom's defenses fall. Waves of bombers are striking from the skies, and an entire company of tanks is tearing apart the helpless infantry. But when all seems lost, a red-haired witch appears from the skies...

Fine and Izetta escape the burning wreckage of the plane on the back of a rifle. But squad of Germanian pilots participating in the invasion of Eylstadt hear the transport's distress call and move to intercept them. Izetta is forced to use her magic to fight them off, breaking the rule her grandmother gave her. When the enemy planes are shot down and driven away, Izetta takes Fine to join the retreating Eylstadt army, where she reminisces about how they met.

Germania has loaded a massive bomb with magical energy that threatens to destroy the entire Dukedom. It will launch soon, and the only way to stop it is to defeat Sophie. Using the magic stone, Izetta flies to Germania for one final battle.

The capital of Landsbruck has fallen, and Izetta and the princess are chased into the mountains. As the imperial forces track them down, Seig makes Izetta an offer: he's willing to give her the other half of Sophie's magic stone. With this powerful item she fight toe-to-toe with Germania's witch, but it causes the user tremendous pain, and shortens their lifespan...

Izetta has been defeated by Sophie, the true White Witch. Sophie is out for revenge against the Dukedom for the crimes their ancestors committed, and she'll gladly work with Germania if they'll help her destroy it. Izetta and the princess barely escape to a hidden fortress in the mountains, but Izetta is so badly injured she can't walk. How can she stop Sophie from destroying her country?

Young princess Fine, the daughter of the Archduke of a small alpine country, travels to the neutral land of Westria to seek help against the Germanian empire that is invading her kingdom. But her plans go awry when she's captured by the Germanians, and transported by air back to their capital of Neu-Berlin. Then a strange light appears at the back of the plane, and a witch begins to awaken...

Tazuna and Koyori battle Awaza Kodama a second time, and she's just as powerful as the first. Tazuna, and Single Gear, cannot hope to defeat her. Their only choice is to rely on Koyori's unseen strength.

Tazuna and Koyori meet their next opponent: Kodama, a powerful idol singer who has defeated many other Hand Shakers. She and her producer are their toughest opponent yet, and together, they overwhelm Single Gear. Tazuna barely escapes into the water below a nearby bridge...

It's time for the School Festival, and Tazuna's class is in big trouble! The machinery's broken and the cooks broke their arm, and they've got no way to get the cheap ingredients they need for their food stall. Can Tazuna use the connections he's made so far to make everything right? And can Koyori learn to cook in time?

Lily and Masaru insist on fighting Single Gear, despite Tazuna's fervent protests. The two of them use cards: Lily, her Tarots, and Masaru, his precious memories deck. But because Masaru is using the same strategy he does in the game, Koyori knows how to beat him. Can she share this with Tazuna when she isn't able to speak?

Koyori gets separated from Tazuna, and because she doesn't have a cellphone, she doesn't have a way to get in touch with him. Fortunately, she's found by President Lily and her little brother Masaru, who take her to play the new game, Precious Memories. Koyori shows an amazing talent for the game, but things take a sudden turn when Lily and Masaru are revealed to be Hand Shakers as well.

After the battle inside the Ziggurat, Chizuru and Hayate are horrified to find out that their victory would have cost Koyori her life. They agree to help Tazuna and Koyori, even though they're out of the fight now. They tell the two of them that in order not to be found in the real world, they need to come up with a name to use inside the Ziggurat when they fight. After a bit of thought, Tazuna and Koyori's new name becomes "Single Gear".

Tazuna meets Chizuru and Hayate, the pair who's car he fixed on the day he met Koyori. They're workers for a major food corporation in the area, and they offer to treat him and Koyori to dinner as a thank you. But after the meal, they reveal that they're actually Hand Shakers themselves!

Tazuna and his new friend Koyori have a problem: If Tazuna lets go of Koyori's hand, she'll die! Can he take her home with him and explain to his parents why he now has to live with a girl? And how's he going to take a bath with her!?

Tazuna and Koyori are facing off against Koyori's sister and the doc's old partner. Koyori's sister has been reduced to an emotionless mute after years of difficult treatments and abuse. Can the two of them bear to hurt someone so close to Koyori? And even if so, can they win against Handshakers who are so much more powerful and determined?

Makihara once had a partner, and a boss. Together they researched the Ziggurat, and the mystery of Babel's revelations. But when a pair of Hand Shaker children were born, their lives changed. The children were constantly targeted, and if they were defeated, they would die. Makihara and his partner tried their best to defend the children, but years of fighting wore them down, and they had a falling out. Now his partner is back, and he has a demand: put Koyori back to sleep forever, and separate her from Tazuna.

With the last of their foes vanquished, and Koyori now having the ability to talk, it's time for her and Tazuna to take up a part time job at the local Cocktail Corn. It's a time to reflect on what's gone on so far, meet old friends, and ready the pair for the future.

Tazuna is a young boy who loves to fix things. But his life takes an unexpected turn when he meets a girl who's lying on a hospital bed in an electronically locked lab. When he takes her hand, he finds out that he can never let go, or she will die. On top of that, he has to battle a man and his partner in something called the Ziggurat, and he doesn't have a power of his own. Can he unlock the might of the Hand Shakers?